This is heady stuff, and in my November 2019 Plastic & Reconstructive Surgery Journal in the experimental studies section. “Nanofat Cell Aggregates: A Nearly Constitutive Stromal Cell Inoculum for Regenerative Site Specific Therapies.”
Wooh! What a title. Now to translate. Basically this is looking at how we get nanofat (which I LOVE. Read about it on my page devoted to facial fat transfer.) which I use in fat transfer surgery.
Nanofat is awesome. I use it to inject stem cells into the skin itself. It helps skin quality, softens wrinkles, and makes everything look glowy.
The question is how do you get the nanofat?
There are two basic techniques: one is “mechanical disaggregate” where you are physically breaking up the fat into smaller particles. The other is to use enzymes, which is called “stromal vascular fraction.”
Study looked at the nanofat samples to find which one had more viable cells.
Findings? Nanofat by mechanical disaggregation worked way better. “Mechanical disaggregation offers a better cell inoculum and uses 10 times less fat tissue as a starting material and delivers a higher cell yield.
What do I think?
Awesome. Mechanical disaggregation is what I do. It works. It’s easy. I love it. Good to know it is the better way to do it as well.