Healthspan, Longevity, Aging better What biohacking has taught me

I am a prototype of a significant number of my patients: middle aged (*sigh*), professional with a consuming but awesome job, mother who had kids at an older age, and a health conscious woman.

My journey started with how can I age better? I find medicine is too reactionary- they wait until you have diabetes, high blood pressure, or heart disease to treat it. What can we do to prevent it? Optimize ourselves? My father died in his early 50s. My genetics aren’t setting me up for success. So what can?

This started my focus on healthspan and longevity. Many would call this biohacking, but when I hear biohacking it makes me think of people trying to sell me snake oil and supplements. I have taken a science driven approach to how to age better. This deep knowledge has led me to become an advisor for Biohackr Health.

It is an exciting time. There are real things you can do which will help you age better- heart health, diabetes, dementia, muscle mass, hormones, and more. There are tests and monitors available to give you true insights into how to age better. What we have found is 1. prevention is everything and you should start now, and 2. there is such an individual response to everything. When thinking about all of the areas of the body it could be overwhelming. You cannot throw the kitchen sink at everything- it is too much. You need to figure out what YOUR issues are and focus on those.

For WEIGHT and EPIGENETICS please see those pages.

What are major antiaging areas to evaluate?

General antiaging focuses on your body at a cellular level. This focus is on things like:

  • NAD levels (which are testable!) and your mitochondrial health. Mitochondria are the powerhouse of the cell. Better mitochondria improve every system in your body
  • Current aging. You can look at telomere length- your telomeres shorten as cells replicate over time, and this leads to the signs we see as aging. You can also look at methylation, which is affected by genetics and environment/habits, and methylation tends to decline as we age. (Read my page on epigenetics)
  • Muscle mass. Turns out building muscle is super important as you age. It isn’t cardio- it is resistance training and weight lifting. Not only does this help with weight, it helps with bone strength, heart health, diabetes, and dementia prevention.

These are all TESTABLE. That means don’t blindly do things. Test. Where are you at? Treat. Retest. Did the treatments help?

I will break it down into some important areas below. This is general advice, and we will review it clinic with you. For more in depth, we can recommend a visit with a longevity doctor.

heart health

Heart disease continues to be the number one killer for everyone, men and women. In my deep dive research, there was a great study that looked at middle aged people with no risk factors, and they did in depth labwork on them and a cardiac calcium scan to look for early atherosclerosis. What did they find? 20% of people who were healthy, with no risk factors had evidence of disease. This was silent disease. They are at risk and did not know it.

So what do you do? TEST.

  • Comprehensive lipid panel. You need to go beyond just HDL and LDL. Have you heard of lipoprotein a? Apoprotein B? These are important markers of your atherosclerosis risk.
  • Blood glucose evaluation. What is your Hemoglobin A1c? This is a general test which shows your blood sugar level. Are you prediabetic? Diabetic?
  • Cardiac Calcium Scan. If you are at risk genetically, high LDL / Lipoprotein a / ApoB cholesterol consider getting tested.  Again, in the study mentioned above of 1000 40-60 year olds who were healthy with NO risk factors, 25% of them showed evidence of atherosclerosis. Particularly for women after menopause (estrogen is heart protective), getting an evaluation is key.
  • Cardiac risk score. Do a risk calculator HERE

blood sugar

Blood sugar is potentially the root cause of all major issues– inflammation, dementia, heart disease, diabetes, weight gain, and cancer. You are at risk from genetics, weight, and aging.

How do you evaluate it?

Historically people check a fasting blood sugar (which you want to be below 100), but a more accurate level is to look at hemoglobin A1c, HbA1c, which shows your average blood sugar over the past 3 months. If this number is over 5.6, you are prediabetic, if above 6.4% you are diabetic.

Important facts:

  • Diabetes risk goes up with age, post menopause, and with weight gain
  • You can find out what spikes your blood sugar. I am a huge fan of continuous glucose monitors. What spikes you is different than what spikes me. Quantity, eating carbs with protein/fats, when you eat, if you exercise all have effects.
  • Insulin resistance leads to weight gain.
  • Treatments can involve diet, exercise, intermittent fasting, metformin, and GLP-1 medications like semaglutide, tirzepatide and more.

You cannot talk about healthspan and longevity without addressing blood glucose. You hear many of the antiaging gurus talking about intermittent fasting – some only eating one meal a day- for this reason.

Build muscle

It is crazy, but as you get older you lose muscle mass. If you are on a GLP weight loss medication you lose muscle mass. If you are vegetarian and vegan, you likely need help building muscle. Doing aerobic exercise is not adquate- you have to focus on weight lifting and resistance training.

So, yes, I have become one of those people in the gym, with resistance bands and TRX and sit ups and kettle balls.

Creatine is a supplement which helps build muscle. I was a nay sayer at first. I thought, “it’s dangerous” or “its for the bro guys in the gym.” Turns out I was wrong. I did a deep dive into it and found it is incredibly safe and effective. I only recommend high quality product that is stable and studied, so I recommend the micronized German creatine powder. We carry it in our office, or you can buy at the Biohackr Store. SHOP

Why care?

The kicker for me was a great study showing that higher muscle mass PREVENTS DEMENTIA. Add that to the other benefits in strength, bone  health, lower diabetes, lower fall risk, better metabolism and weight control, its pretty compelling:

  • Increased Strength – Stronger muscles make everyday activities easier and improve overall functional movement.
  • Better Metabolism – Muscle tissue burns more calories at rest than fat, helping with weight management.
  • Improved Bone Density – Strength training enhances bone health, reducing the risk of osteoporosis.
  • Joint Support & Injury Prevention – Muscles help support joints, lowering the likelihood of injuries. (The risk of falling when you are older? Hip fracture mortality within a year is = to your age)
  • Enhanced Athletic Performance – More muscle means better endurance, speed, and power in sports.
  • Mental Health Boost – Exercise releases endorphins, reducing stress and improving mood.
  • Increased Longevity – Studies show muscle mass contributes to a longer, healthier life.
  • Blood Sugar Control – Helps regulate glucose levels, reducing the risk of diabetes.
  • Better Posture & Balance – Strong muscles support proper alignment and stability

Hormones + Menopause

This is such a big topic that I have a whole page already on it and dozens of blogs. Why? When I reached menopause- even though I have seen what it does to women over and over- I was still stunned to see the effects. It is like going off a cliff, and everything changes- skin tone, drooping, sagging, cholesterol levels, blood sugar, weight, breast size. You feel like your body is hijacked.

I won’t repeat all of it here. Basic facts:

  • Hormone supplements during the perimenopause time and in menopause are generally recommended now. This is due to debunking the incorrect interpretation of the WHI study.
  • Hormone replacement lowers your risk of heart disease, dementia, and bone loss.
  • If you have a uterus, you need to do estrogen and progesterone. This does have a small but real increase in breast cancer risk. This is a conversation you need to have with your doctor. There are risk calculators for osteoporosis, heart disease, and breast cancer to help you. If you don’t have a uterus, estrogen alone can be given, and studies show this LOWERS your risk of breast cancer.
  • Vaginal estrogen at low/moderate doses does not get absorbed systemically.
  • You need to start hormones early, ie soon around the time of menopause.
  • Many physicians are out of date with current recommendations. It is for this reason I went into a rabbit hole of educating myself when I was going through it. This led me to being an advisor for Midi Health and Biohackr Health.

For more in depth, go to my menopause page HERE, which has links to my blogs on estrogen and menopause. My blogs will cite the original scientific publications or books which I draw from.

what you eat matters

Diet matters. We all know this. From the Mediterranean diet being associated with lower heart disease, to seeing high vegetable diets help keep your telomeres longer (antiaging), to studies which show lower infection rates and prettier scars in abdominoplasty patients who protein load before and after surgery, what you eat matters.

From a body health perspective, general diet recommendations:

  • High vegetable
  • Know your blood sugar
  • High protein (usually the recommended dose is 1 gram/kg of body weight)
  • Supplements should be USP or NSF certified (so you know what you are getting), and before going hog wild on supplements, strongly consider testing your micronutrients to see what you are deficient in. Supplements are medications, and I have seen patients in liver failure from them.
  • Eat variety.
  • Eat whole foods, not processed. It is better to eat an orange, than have orange juice.
  • Probiotics and your gut microbiome are important. As we understand it more, we see correlations with many disease processes (heart disease, MS, Crohns) and your gut flora.